The Quantum Engine is a cross-language 32bit native code compiler and light-weight IDE that has an advanced 2D game engine for PC's running Microsoft Windows® and uses Direct3D® for hardware accelerated rendering. It's robust, designed for easy use and suitable for making all types of 2D games and other graphic simulations.

Below is footage of the demo game made with Quantum Engine.  Sure it's only an asteroids clone, but it looks mighty pretty.  Anyway, if you're in the market for a 2D game creation kit, this could be right up your street. Click here for more details.