Not quite sure how this would actually work, but the unique slant on traditional 2D RPGs taken by Orbis Infinitas is that everything in the game is procedurally generated, including the world itself, cities and towns, dungeons and forests, empires and politics, characters and monsters, even the story, background and quest system! Everything will be generated on the fly and a player can be part of a world that seems to have no borders. You can walk and walk into one direction and maybe you will never find the end of the world.
The game's IndieGoGo Campaign has started very recently and they haven't got off the ground at all yet. It's being developed for PC, Mac and Linux.
If you're interested in procedurally-generated games, you may also want to check out Tiny Trek.
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